SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. All rights reserved. Most labs give separate results for each condition theyre screening for. Amnio specialist also told me that low fetal fraction can be because of placenta. Results from first trimester screening came back low for t21, t13, t18 My doctor just did not liked that NT measured 2.6mm and that was the reason she sent me to do NIPT. Are there other tests I can take to find out my risks? Does anyone know? The reason that your doctor is suggesting an ammio is because studies have shown there is a positive correlation between a low percentage of fetal DNA (i.e. Your post will be hidden and deleted by moderators. Get useful, helpful and relevant health + wellness information. Now at 16w they were both under 2. Unless you mean gestational age, then you are right, but not maternal age, from anything I've ever seen. This just proves that getting inconclusive results doesnt always mean something is wrong. This time around I used Myriad Prequel, which has a technology that prevents most (maybe all?) Yes please do let me know what helped you. Its important to remember that a screening test estimates the likelihood of the fetus having a particular condition. However, they got all the ones they needed for the NIPT which were good. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Maybe call the clinic directly for feedback on how that particular radiologist writes reports. When I called for test results over a week later, they said they had needed to test the second tube as the first had failed. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. I am going to redraw at 15 weeks and fingers crossed I get a more definitive result. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Same situation here! The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? My Hi all,I had my first NIPT labs drawn around 10 weeks. DNA makes up a persons genes and chromosomes, and gives healthcare providers a glimpse into the fetuss genetic makeup. This educational content is not medical or diagnostic advice. The first rest was done around 10 weeks and the second around 14 weeks. I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. My next appt is my anatomy scan and it isnt until Nov 30! Your test results may sometimes be hard to interpret, so ask your healthcare provider for help if youre unsure. Healthcare providers may recommend it if you: The American College of Obstetricians and Gynecologists (ACOG) used only to recommend NIPT for pregnant people considered high risk. Learn more about, Twins & Multiples: Your Tentative Time Table. Taylor-Phillips S, Freeman K, Geppert J, et al. How far along were you when you took each one? They tell your provider how likely it is that a condition exists. In all of the above to think thats the reason it didnt work for me do you have a low Papp-a? yeah I declined the redraw also and decided to wait. Now doing the waiting game!! It just means they don't have enough information to make any kind of conclusion. Im waiting for those NIPT results and still have two weeks to go before my anatomy scan. Its done by taking a sample of your blood, which also contains fragments of DNA from the fetus. This happened to me as well. Lab is saying I could try a third time but no guarantees it will work. praying for you and your son or daughter to receive good results! Were having a boy! The CVS came back perfect - no abnormalities. @Woofwoofbarkbark ya I definitely want to know as early as possible, t13/t18 have such such high chance of late miscarriage etc I need to be prepared if this was a chance To comment on this thread you need to create a Mumsnet account. Create an account to follow your favorite communities and start taking part in conversations. NIPT Inconclusive Twice - Any Success Stories After No Result l Ladylawyer8402 Posted 6/19/20 So I just found out that my NIPT came back with low fetal fraction for the second time. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. insufficient DNA for the NIPT test) and chances of a trisomy defect. you can always do amnio if you need results. This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. Most NIPT tests screen for: An extra chromosome causes Down syndrome, trisomy 18 and trisomy 13. I wish you well mama! Ultimately, we learned we were having a baby girl who did not test positive for trisomy but have still been advised to do an amniocentesis procedure at 16 weeks for ultimate peace of mind. Inconclusive just means they couldn't get a reading. There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. Its important that you talk to your healthcare provider about your results and options to get more information. 69 0 obj
<>
endobj
The results will be on this week for a few things but up to 2 weeks for everything. Talk to your healthcare provider or a genetic counselor about your concerns. You may have questions about what your results mean or if you should even have the NIPT test. We had two inconclusive NIPT tests (from two different testing companies). Hi! Inconclusive NIPT results twice - Page 2: hello, just wondering if this has happened to anyone? I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. I had to wait about 10 days for bouth times I did NIPT, only to get inconclusive results. Create an account or log in to participate. Please whitelist our site to get all the best deals and offers from our partners. NIPT Sex chromosome aneuploidy or fetal sex inconclusive You recently had a blood test to screen for chromosome disorders in the fetus and were told: amount of DNA is from the pregnancy. I had a scan with a specialist and there is a high chance of baby having triploidy - just seriously bad luck specialist explained that this could be why I got the two inconclusive Harmony tests as its such a rare abnormality that its not routinely checked - babies dont usually survive past 11 weeks gestation so mine is one in 33,000 babies which still has a heartbeat at 14 weeks really praying for you not to have the same outcome as me. However, its now recommended that providers offer NIPT to all pregnant people, regardless of risk. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. Inconclusive NIPT twice. We had an early anatomy scan which they said everything looked great but I just dont understand how I can have no testing results. Nothing! Hope you are getting all the support you need and sending good healthy babe energy your way! Not all NIPT panels evaluate for the same conditions. 1997-2023 BabyCenter, LLC, a Ziff Davis company. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. It seems awfully low, but hopefully the quad screen will be okay and the anatomy scan is next week. Remember, only you and your family can decide whats best for you. We had issues with our genetic testing as well and I too was super worried! I also have a bloodclot that I am on Lovenox for which adjust my blood levels, could this effect these results? Its nerve racking, but I'm hoping to hear some good news soon. Same thing happened to me. NIPT cant screen for all chromosomal or genetic conditions. The NIPT measures the fetal cfDNA in the mother's bloodstream, which comes from the placenta. Your cells are constantly dividing and creating new cells. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. That is heartbreaking. Theyre not sure what caused the inconclusives, but theyre screening and not diagnostics, so it could just be in error. I dont think Im obese but definitely cons. Youre little one made it this far, hopefully your little one is strong! This is called the fetal fraction. I am assuming they will suggest more invasive testing? . Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Yes, Harmony is NIPT. I have never heard of two inconclusive results! NIPT testing doesnt diagnose conditions it only suggests a fetus is more likely to have a particular condition. I just wish you luck with your anatomy scan and hope all is well! If my screening test is positive, what are the next steps? The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. Im so so sorry to hear about your loss. It doesnt diagnose a condition. Which is less than it would normally be for my age. also people mentioned placenta issues above! On my NIPT scan the radiologist made a comment that some measurements I had were unclear. Find advice, support and good company (and some stuff just for fun). This test can be done beginning at 10 weeks of pregnancy. Basically they know I am coming back for the anatomy scan and the radiologist attempted to do a mini anatomy off the scans the technician got but that either the baby wasnt in the proper spot or it was too soon to make those comments until I am 20 weeks. This pregnancy has been so stressful so far 0 We offer women's health services, obstetrics and gynecology throughout Northeast Ohio and beyond. HW[o[~G~ mHc}pHV"=. (https://www.nichd.nih.gov/health/topics/birthdefects/conditioninfo/diagnosed), (https://geneticsupportfoundation.org/pregnancy-101/). Its soo nerve breaking!! Are you taking aspirin? think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Also at 13w3days I had my. I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. So bizarre this happens. Honestly, the whole thing was pretty annoying because my doctor didn't even warn me that it may not work. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Other factors like being pregnant with multiples, being a surrogate or having obesity can affect NIPT results. Has anyone had this? The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. She said it worked for almost all her patients. What is noninvasive prenatal testing and what disorders can it screen for? Originally my doctor said we would take another blood sample once I was further along around 16 weeks and try again if it didn't work initially. the most helpful and trustworthy pregnancy and parenting information. That is what the clinic told me. Both said due to low fetal DNA at 2.6% and 2.7% respectively. 2005-2023Everyday Health, Inc., a Ziff Davis company. On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. Learn more about, Twins & Multiples: Your Tentative Time Table. I have also read that certain medications can interfere so that is totally possible that its what happened in your case. For the most . The following questions might be helpful to you as you make your decision: NIPT testing costs vary. Use of this site is subject to our terms of use and privacy policy. They could have also just waited until 16 weeks for my first blood draw given my weight. Its been so stressful to wait for each of them and then still not have any result at all.. I fully understand your need for answers - I felt exactly the same way and its much better to have a yes/no answer through CVS/amniocentesis than keep guessing etc. Ocean/sky themed baby girl nursery - finished at 38+ A hilarious moment that made me excited to have my kid. I took the testing at 16 was I. You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Note that once you confirm, this action cannot be undone. What youre referring to is the NP test. hYmo6+bDR$EE iZcKZ2,5V~b)%7QGx{8qfs&,9K
dbyb:,Xg1cekX3)-l`Gj%SV0H@1#43*a?+V1bM4^%}*&29Li1I=&~~K&a/e2,VaLFEZE]&7_4NO\Vq9z2.U\b1)0[$@'NmY=B(db~O^6jRJfbZ&\fMeY?RPu A]LaR2rt$\.E=_&ShK+05}rYo"&7xJ|10&,*NOop;~\@`zPd40`Qq[BlJMOnsgU*|]yepYE.+yf However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for . If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. This is my second baby and I didnt do NIPT with my first. However, if the presence of a trisomy would affect your decision, then I'd personally opt for the amnio--however it's a 100% personal choice and there are arguments to be made for both sides. I'm so sorry your going through this stressful situation , Got the quad back! A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Yes, NIPT can be done anytime after 10 weeks of pregnancy. Has this happened to anyone else? Another inconclusive result. NIPT also includes a study of the sex chromosomes, but a result is not always possible. *_xCeEm Di?z&>#m`X_ )=
(https://www.nichd.nih.gov/health/topics/preconceptioncare/conditioninfo/tests-needed). She didnt suggest further testing. Are you tall? Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. My Hi all,I had my first NIPT labs drawn around 10 weeks. I waited 13 days for my Harmony test results and the nurse finally called me back today to tell me my test was inconclusive! Have had an earlier screening test that suggests a potential problem. Im 34. NIPT tests are safe, and theres no risk to the fetus. - May 2020 Babies | Forums | What to Expect Community > Birth Month May 2020 Babies 97K Discussions 192K Members The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. 107 0 obj
<>stream
I did IVF and my embryo was a normal embryo through pgt so that gives me hope. Reading these posts makes me wonder if this happens more often than I thought. We do not endorse non-Cleveland Clinic products or services. I realize I may have been taking about something different. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). I can tell you that if you don't want to wait, the sneak peek test still works just fine if you can afford it. Or chromosomes? My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. The accuracy of the test varies by the condition that its checking for. Press J to jump to the feed. It's not like my weight was a surprise to them. I have read this is an issue for plus size women and the other factor is age. Its nerve racking, but I'm hoping to hear some good news soon. NIPT stands for noninvasive prenatal testing. I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. So odd! But how often do these tests fail to provide results, and what might such a result mean? My doctor didnt seem too concerned, as apparently they come back inconclusive all the time. How do health care providers diagnose birth defects? Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. So after 9 weeks of genetic testing and no results we were finally able to get results and everything has turned out ok and we are having a baby boy! Your post will be hidden and deleted by moderators. your experiences with being fat an needing IVF/ICSI? Hi all, just an update. If youre having a difficult time or wish to discuss the screenings in more detail, a genetic counselor can help you understand the prenatal testing options and what may be a good fit for you. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Mine came back inconclusive twice. Meet other parents of January 2020 babies and share the joys and challenges as your children grow. It requires drawing blood from the pregnant person only. 1997-2023 BabyCenter, LLC, a Ziff Davis company. Ans to top it off I really wanted to find out the gender and now I dont even know if things are ok. I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. It's probably your BMI. Inconclusive NIPT result twice w wjhall I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. I had the test done again about 2 weeks later and just got results today. The quad screening and 12 week ultrasound are more likely to actually work and give back results. Im now worried something could be wrong with my baby. Strangely enough, I am also on lovenox.I am also old at 39 and have a higher BMI. BabyCenter may earn a commission from shopping links. My nipt/panorama/harmony results came back inconclusive both times. The test can also determine the sex of the fetus. My doctor told me to test then and acted as if that wasnt too early. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Has this happened to anyone? u 03-(q}|$05`- H320mf`~e0 *
Another inconclusive result. Based on the results of the NIPT test, your obstetrician may recommend diagnostic tests. 15/01/2022 20:53. NIPT doesnt test for all chromosomal conditions or birth disorders. The test can also determine the sex of the fetus. Would you get the NIPT test if you were me? yes, I have the 12 week scan scheduled for tomorrow evening + bloods then - maybe it will be a different lab this time and it will work. When cells break down, tiny DNA fragments are released into your bloodstream. Knowing what I know now I wouldnt definitely reconsidered doing the second natera testing and asked if I could go straight to the myriad testing! Inconclusive NIPT results. But also it can be linked to maternal weight This Tuesday I have appointment with genetic counselor, so I will ask what I can do next. I didn't even want them to do that. Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Are you overweight? Have a child with a chromosomal abnormality. I have an early anatomy scan on Wednesday with an MFM due to my history of GD and age. This educational content is not medical or diagnostic advice. Im so so very sorry. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Your DNA is inside all of your cells. They could well be inaccurate- most companies require at least 3%. My first pregnancy resulted in a miscarriage at 8 weeks. Were my expectations of postpartum help from my mom Press J to jump to the feed. The most common sex chromosome conditions are Turner syndrome, Klinefelter syndrome, Triple X syndrome and XYY syndrome. They didnt find anything wrong. Create an account or log in to participate. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Unlike most DNA, which is found inside a cell's . We will not be doing anymore testing for baby boy #3. Has anyone had this happen to them or know someone? They kinda downplayed it saying it happens a lot, but it still stresses me out a little. Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. We had anatomy scan this week and everything seems okay. This testing analyzes small fragments of DNA that are circulating in a pregnant woman's blood. I dont think Im obese but definitely considered overweight. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. I have read this is an issue for plus size women and . By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Your test result shows that your pregnancy is at low risk for these three conditions. Are you doing the NT scan & bloods as well? We just got our results back and have a perfectly healthy eggo. I've seen a few posts about on this sub from women who had insufficient fetal DNA because of their weight and had to go back for another draw. Whether patients are referred to us or already have a Cleveland Clinic ob/gyn, we work closely with them to offer treatment recommendations and follow-up care to help you receive the best outcome. endstream
endobj
startxref
. It has a heartbeat of 142 but doctor said that hes still very guarded about the pregnancy and strongly advised for the CVS which I will do. Im going for my ultrasound next Wednesday and Im kind of nervous. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didn't tell me over the phone what it was. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Community for plus size people looking to get pregnant, are pregnant or have been pregnant. Now it is considered high risk and listed a 1/17 chance of a chromosome issue. Learn more about, Twins & Multiples: Your Tentative Time Table. This limbo state is the worst. Your provider obtains a blood sample through a vein in your arm. H Hawaiimomma22 Nov 30, 2017 at 12:44 AM @veneziana, . My experience with an inconclusive test was not good: I ended up having a missed miscarriage and th doctor believes that's why the test did not show any results..as there was not enjoying baby dna sample. k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M
9z:FC& Q~Ro1!. Wish we did like other pregnancies and skipped the testing! You have a small amount of the fetuss DNA circulating in your bloodstream during pregnancy. Anyone else go through this and get good results? Inconclusive NIPT results twice : hello, just wondering if this has happened to anyone? It just depends on the baby. Prenatal tests like NIPT are optional, and getting the test is entirely up to you. We are going to do the quad screen and a detailed ultrasound next week. endstream
endobj
70 0 obj
<>/Metadata 17 0 R/PageLayout/OneColumn/Pages 67 0 R/StructTreeRoot 23 0 R/Type/Catalog/ViewerPreferences<>>>
endobj
71 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>>
endobj
72 0 obj
<>stream
Theres also the possibility that no test results are given due to insufficient fetal DNA in your blood or difficulty identifying fetal DNA. I am way larger than you. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Anyone have wrong gender results? I had a d and c and fell pregnant immediately. Your healthcare provider can best guide you in these situations. I'm 36 weeks now. Create an account or log in to participate. When I went back for a second blood draw, they took two tubes of blood. , I agree with PP. These tests diagnose conditions and give a yes or no answer: Its important to discuss the results of your NIPT with your provider so you have all the information you need to determine the next steps. I am so sorry this has happened twice! Fortunately got low risk for chromosomal anomalies Just the baby's sex was inconclusive! Obviously not out of the woods but the good news is all I needed to keep tracking forward with positivity. NIPT testing can be done as early as 10 weeks of pregnancy through delivery. Just got my results back yesterday with a BMI of 47. My risk just due age is 1/94 for trisomy 13, 18. thank you so much. Well this clinic doesnt ask people to come back. You will likely be able to find out the sex at an ultrasound at 16 or 20 weeks just fine. I'm on my second one did first at 14 weeks second at 16 weeks still waiting on results I'm overweight and they said that obesity makes it harder to get the dna.ive had several scans and no soft markers found. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Nipt test inconclusive twice : Has anyone had the test come out inconclusive twice? Im going through the exact same. Its important to note that it takes about 10 weeks for enough fetal DNA to circulate in your blood. They send this sample to a lab to analyze it for specific conditions. You apparently have too much blood for an accurate reading. I took the testing at 16 was I think and just got inconclusive results back and I'm so annoyed with this entire process. They didn't even bother to retest mine when the first try came back inconclusive because they assumed it wouldn't work since I'm obese. Please specify a reason for deleting this reply from the community. Any of you ladies have an update? We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! During this test, your provider takes a sample of your blood to look for abnormalities in the fetuss DNA. Most health insurances cover most (if not all) of the cost. We strive to provide you with a high quality community experience. But I was told they like to comment on everything they see based on the technicians scans. Has anyone had the test come out inconclusive twice? A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I also did NIPT twice and bouth times it came back inconclusive due to low fetal fraction. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. I hate the thought of ending your babys life especially if the doctors have it wrong.
Baker Funeral Home : Queensbury Ny,